Peter Diamandis and Tony Robbins on strategies that promote longevity now – and in the near future

Peter Diamandis and Tony Robbins on strategies that promote longevity now – and in the near future

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[Dr. Patrick]: Hello, friends. This episode  has two amazing, amazing guests who need   no introduction, Dr. Peter Diamandis and Tony  Robbins. Neither of them really do need an intro.   So I'm going to keep it really, really brief.  Dr. Peter Diamandis is a serial entrepreneur,   founder of XPRIZE, which designs and operates  global competitions to incentivize the development   of technological breakthroughs that can accelerate  humanity toward a better future. Tony Robbins is   a serial entrepreneur. He's a number one "New York  Times" best-selling author, he's a philanthropist,   and he's the nation's number one life and business  strategist. And both of them are so much more.

I kind of wanted to kick this off because I'm  personally curious. Peter, you're really well   known for being perhaps uniquely motivated  in finding systems and organizational level   approaches to creatively solving big problems,  XPRIZE being one such example. On the other hand,   Tony your work focuses more on the individual  and in helping people solve their own internal   problems, whatever they are for, you know,  whatever's holding them back. So there's   definitely some potential overlap here, but maybe  you could tell us a little bit about how you   both connected to form such a strong, lasting  friendship and collaboration over the years. [Tony]: Well, we've been friends for a long  time, but this book came together with us   together because I had an accident that they  told me was going to end my career. I was being  

an idiot chasing a 22 year old professional  snowboarder down a mountain, and I couldn't   make the moves they were making, and it ended in  disaster. I thought I literally broke my neck.   In the end, I tore my rotator cuff severely, and  the pain was nine-nine pain, because it was nerve   pain. I couldn't sleep. What do you do? You go to  your doctor's. I went to four doctors, all of them   saying surgery, surgery, surgery. Well, what's the  prognosis? Well, I'll be honest with you, you may   not be able to lift your arm above your shoulder  again. It could tear again. Four to six months of  

recovery, I asked them about stem cells because  I worked with some of the greatest athletes in   history. You know, someone like Cristiano Ronaldo  was supposed to be out for three months, it was   two and a half weeks, and he's back on because of  stem cells. And so, no, no, no, they're worthless. And then the final doctor looked  me straight in the face and said,   "I want to show you something. Life as you know  it is over." These were literally his words to me.   And I said, "You clearly didn't  go to my communication seminar."   But he showed me my spine, and he said, "This is  no laughing matter." He said, "One good hit," and   he said, "You won't be able to walk again.  No more running, no more jumping, you know,  

no more snowboarding, that's for sure." And, you  know, if you're ready for a punch in the gut,   you might handle it. I didn't handle it so well,  I got to be honest, for a few hours, and then my   normal brain kicked in and said, "There's got to  be better solutions." So, Peter and I have been   different for years and partners in business. So  I called the genius over here and said, "Listen,   you know, who's the best person on stem cells?  I've heard good, bad, and between." And he said,  

"You got to reach out to Bob Hariri." Why don't  you share with him a little bit about that, peter? [Dr. Diamandis]: Yeah, sure. So,  like you said Rhonda, I've been   focused on large-scale solutions, and for  probably the last 15-20 years, it's been around   how to use exponential technologies to solve  the world's biggest problems, you know, AI,   robotics, 3D printing, synthetic biology,  quantum computing, all of these areas. And   I became enamored about eight years ago on the  idea of using those exponential technologies,   focusing it on health and longevity.  You know, as you get older,   you know, space is taking a long time, I wanted  to live as long as I can. And I met Bob Hariri  

years ago, these were both pilots, he's passionate  about space, and became just fascinated by what   Bob was doing. Bob had been one of the very first  people ever to isolate stem cells from placentas. In fact, he said, you know, "The placenta is the  richest source of stem cells out there, and these   are like, you know, day zero old stem cells."  And I had helped him spin the company, a company   called Cellularity, out of Celgene where he was  the head of cellular medicine, and we formed this   company to have stem cells from the placenta being  able to be used eventually for repairing the body.  

And so when Tony reached out, I said, "Tony,  listen, you've got to talk with Bob Hariri. He's   like the world's expert in stem cells. He's  my go-to guy in this field." And stem cells   are how you can rejuvenate the different systems  and tissues of the body. So, Tony, back to you. [Tony]: Yeah. So, little I know, it's like  saying I want to learn about basketball,   and he goes, "Let me introduce my friend,  LeBron James, you know." So, I talked to Bob,  

and Bob said, "Listen, you know, using your  own stem cells is a waste of time after 40,   they dropped through the floor." He said, "If  you're doing an elbow or an ankle or something,   maybe," but he said, "This is really extensive.  You need four day old stem cells." And I said,   "Fetal tissue? I don't have fetal." He said,  "No, not fetal tissue," and he explained,  

you know, the power of placenta and the  power obviously of cords. And he said,   "I'll tell you where to go." He said,  "You can always go back for surgery." So,   I went for it, and I did three days of treatment.  It was just 20 minutes a day of an IV and a shot.   And, you know, the first day, I felt tired,  the second day, I had a cytokine response. I knew what it was, so it didn't  scare me, but, you know, shaking,   freezing, about 20-25 minutes of that. And then my  body had a very strong reaction. I went to sleep,   and I woke up, not only was my shoulder perfect,  I have done the MRI, I'm totally fine. That was  

almost five years ago...four and a half years  ago. But for the first time in 14 years, I stood   up with no pain in my spine. So, it turned me into  an obsessive one, I want to know everything about   stem cells, what's the greatest breakthroughs  in this area. And then what I began to find out   is not just stem cells, there's this incredible  revolution in regenerative and precision medicine.   And then, you know, every two years, the  Vatican, the Pope actually throws a conference,   probably the biggest in the world, with doctors  from all over the earth because he believes   this is a breakthrough for humanity,  and he wants the answers for humanity. And so Peter was going, and then all of a  sudden, I got a call, and they said, you know,   "We'd like you to be the cleanup speaker," and I  said, "Wonderful, but I want to attend the whole   thing." And so I attended the conference,  and I met some of the greatest scientists  

alive in rehabilitative medicine and regenerative  medicine and precision medicine. I met patients,   more than a dozen, that were sent home to die  because the cancer wasn't treatable, but they   found somebody like Dr. June with CAR T cells. And  here they were six years later totally healthy.   I met, you know, Jack Nicklaus, one  of the greatest golfers of all time.  

He couldn't stand for more than 10 minutes,  his pain was so severe. They were going to,   you know, lock know, give him a  spinal fusion, which, as I'm sure you know,   doesn't usually work at least half the time,  and if it does, gives you limited mobility.   He did stem cells instead, and here he was  82 years old now playing golf and tennis. So, I just said, "I want to do like what I  did with money. I want to go to the very best,   but instead of 50, you know, the Warren Buffett,  the [inaudible 00:06:33], the Carl Icahn,   let's find the top 150 Nobel laureates,  scientists, medical doctors. Let's interview  

them and bring the very best on how to increase  your energy and your strength and your vitality,   but also what's the best in diagnostics to  prevent it, and what's the best if you're   running into real challenges. And so that's how  this was created. And I went to Peter and said,   "Why don't you join me on this, you genius?"  I went to Bob who helped me. And so the three   of us worked on this project together. It's  been a three year project. And by the way,   we're donating 100% of the profits as I  did in my last three books. We're feeding   20 million meals for feeding America. I'm up to  850 million meals. I committed to a billion meals   seven years ago, and we're ahead of schedule.  And the balance is going to Alzheimer's cancer  

and heart disease research with some  of the best researchers out there. So, we've tried to create something that  people could enter and use as much or as   little simple lifestyle changes, are  things you and I have talked about in   the past, to what are some of the most  high-tech solutions that are available. [Dr. Patrick]: Awesome. We're going to dive into  all that hopefully. On the stem cell front...on   the placenta front, Peter and I were chatting  about this a little bit before off camera.  

I banked my placenta in 2017 with LifebankUSA.  This was mind-blowing to me. You know,   I didn't even know about the source. You know,  the stem cells in the placenta being people hear   the word stem cell, and, you know, it's like,  "Okay, a stem cell, what is that?" It's a cell   that has the capacity to replenish the different  cell types within an organ. But there are stem   cells that can form many different types of  cells in different organs, and so you can have   what's called a pluripotent stem cell, which  can form a cell in your heart, or your liver,   or your brain. And the placenta is actually a rich  source of that. And I didn't [crosstalk 00:08:21] [Dr. Diamandis]: In fact, Rhonda, I would say,  and for anybody listening, if you're pregnant or   someone you know is pregnant, it's something you  should consider to bank, not only the cord blood,   and the cord blood is the hematopoietic  stem cells, it's the stem cells that lead to   red cells, white cells, you know, immune  cells, but if you bank a placenta,   it's rich in these pluripotent stem cells. In  fact, I think that the placenta is a 3D printer  

that manufactures the baby, all of the cells  that make up the baby come from that placenta.   And the placenta is also rich in natural killer  cells and T cells, all these immune cells. And   what LifebankUSA does is it decellularizes the  placenta, it saves those cells. And it's like know, for those of us who remember  a boot disk from your earliest computers,   it's like saving the original  software before it gets corrupted.

And another thing is that the cells from the  placenta haven't developed...they haven't been   thymonized yet, they haven't developed a us  versus them characteristics. So you can give   placental cells to anybody, you know, because  the placenta doesn't generate an immune reaction   against cells and you...don't generate  immune reaction against placental cells. [Tony]: Rhonda, there's also, you know,  one of the people that we met originally,   Peter and I both met, at the Vatican, became  good friends with, and investors in this company,   is a company that's called Biosplice. And they're  in the third stage of FDA trials right now,  

you know but just so your listeners  know, phase one safety, of course,   phase two is efficacy, phase three's  efficacy at scale. So, in the third phase,   they think they'll get approval sometime in the  late fall or the beginning spring of next year.   And literally, they've discovered the Wnt pathway  has been known about, it's the signaling system   that tells your system, "Okay, make this many stem  cells for the brain, this many from the heart."   And as you age, sometimes that signaling  system becomes corrupted or less effective.

Well, they figured out how to upregulate or  downregulate, whether it's cancer we want to   downregulate growth or upregulate, like you want  to get osteoarthritis and you want to regrow   tendons. And so the one they're getting approval  for first is for osteoarthritis. It's a single   injection, and in 11 months, you regrow all your  tendons, but based on the boot disk as was just   described, they're like 16 year old, tendons,  even if you're 40, 50, 60, or 70 years old,   that's the world that we're entering to right now.  So it's like there are things you can do today,   there's things you can do in 12 to 36 months,  and that's what this is focused on, not 10,   20 years from now, what you can  do right now to change your life. [Dr. Patrick]: So, Tony, you're all about  applied health promoting habits. You know, I  

know you're a big time fitness enthusiast, you're  a cold plunger. What are some of your favorite   lifestyle habits that you practice and are most  excited about when it comes to living healthier? [Tony]: I'll tell you what I was least  excited about but have become excited about,   and I give Peter partially credit for this,  but I'd also give Dr. Walker know,   neuroscientists from UC Berkeley, who's kind  of the sleep expert. My whole thing was, "I'll   sleep when I die." You know, it's like my wife  loves eight hours of sleep. I was like four or   five hours is more than enough, I gotta live this  life. And the way He convinced me, Dr. Walker,   was he said, "Tony, we did a study. I think  it'll convince you, 1.6 billion people." I said,  

"Dr. Walker, you couldn't have coordinated  that" because they didn't have to. He said,   "It's called 70 countries that all have daylight  savings time." And he said, "Here's what we found,   an alarming statistic, when we spring forward  and we lose just one hour of sleep, in those 70   countries, over the next three days, heart attacks  increase like clockwork, on average, 24%. When we   fall back and get just one more hour of sleep in  all those countries, heart attacks dropped 21%."

He also does correlations to traffic accidents.  He also showed me that a man who sleeps four   to five hours a night usually has testosterone  levels of a person 10 years older than they are,   that got my attention. So, you know, he taught us  and he's taught all of us some really simple hacks   that I now use, one of those is having a  consistent time to fall asleep and wake   up. And I got to be honest, that one  is not perfect for me by any stretch. But the other is, you know, I was working on  the sleep chapter for the first time at 6:15   having to be up at 9:30 in the morning. So, I  knew something was wrong. But now I really work   to get eight hours, which I've never done  before. I wear a Whoop and I measure it.   I use an eye mask, I keep the temperature about  65 degrees, which allows you to go deeper,   and so I stay away from those blue lights  that... you know, you can wear the little  

goggles if you want, kind of a rose-colored  glasses so your brain can go to sleep easily,   so some really simple things. But for me, I love  cryotherapy, as you know, I love cold therapy.   You were the one that got me into saunas. I  obviously knew about saunas and used them,   but I had no idea the research that showed four  to seven times a week could change completely the   profile of you having a heart attack or a stroke,  to changing a blood pressure. I'm quite religious   on both sides, the cold and the  hot, I find that to be invaluable.   I also do hyperbaric oxygen. I'm a big believer  in pulsed electronic-magnetic frequency, PMF.

I use that as a kind of a biocharger for  my body because, you know, I'm a biohacker,   I got to get up and do 12 to 13 hours with  15 or 20,000 people in a stadium who won't   sit for a three hour movie for four straight  days or seven straight days. And these days,   I just finished a seminar with 800,000 people for  six straight days. Now I've got to do it through a   screen, and I keep people know, I got a  seminar coming up next week or two weeks from now,  

it's 25,000 people in 195 countries. And so we  start here at 10 a.m, my friends in Australia   start at midnight, and we go 12 and a half hours  a day, so they start at midnight and they finish   like 1:30 in the afternoon. My, you know, friends  in, let's say, London are five hours ahead of us,   so they're starting their, you know...  Literally, every time zone in the world,  

I got to hold them together, so the level  of energy this demand is through the roof. And then, of course, there's the understanding  of how do you really impact those mitochondria   through things like understanding NMN,  NAD and what the impact of that is,   which, as I'm sure you know, is  quite powerful to say the least,   especially after you turn 40 or 50 years  old where that drops off the cliff. [Dr. Patrick]: I want to ask Peter sort of  similar question, but before I go there since   you mentioned it like...I mean, anyone that's  seen you in action, whether live or virtual or   on television, Tony, I mean, you've got  incredible mental and physical stamina.   Like what's the secret sauce? Are you disciplined  with these...with your lifestyle factors? Tell us.

[Tony]: I'm extremely disciplined  with my lifestyle factors,   but some of them backfired.  So I was a vegan for 12 years,   and then, you know, when you're burning 11,300  calories...that's my average calorie burn. I   have a group that works with Olympic athletes, and  they traveled with me for three years. They tested   me. I wore a 70,000-dollar device that measured  everything, heart rate variability, they took my   saliva, they took my blood, over 11,300 calories  on an average day on stage 12-hour day. Actually,   the device only lasted nine hours, the battery  died, and I kept going another three hours   in perspective, right? I jump 1000 times,  Rhonda, to give you an idea, in an average day,   and they explain to me, I'm 282 pounds, so  every time I come down, it's four times your   body weight. So imagine 1000 pounds times 1000  jumps, a million pounds of pressure in one day.  

If you saw my bone density, you always said,  these are humans, these are Olympic athletes,   this is something we've never seen, I have 99.9%  higher bone density than anything they've ever   measured, to give you an idea. I have 15 pounds  more of lean muscle mass than the average lineman. If you're running with a friend, and you can't  talk anymore, your lactic acid's about 4. I'm at   18 and still speaking. So, I went from being a  vegan at one stage because it's just burning so  

many calories to having fish, but the fish I chose  unfortunately was salad fish with swordfish and   tuna. And there's one thing Peter and I both teach  people now. You've got to do a blood test around   metals because, unbeknownst to me, those are older  fish, they eat the younger fish, they absorb all   their mercury, plus my DNA did not enough slat[]e  as well just the way I was operated. On a zero   to 5 scale, I was 123, highest they'd ever  measured in the state of New York. The Florida   Health Department was notified by New York. They  came out and investigated, talked to my staff,  

they thought my wife was trying to kill me  because I have a large life insurance policy.   Was not true, it was the fish. So, sometimes  you're trying to be really disciplined. So I've been very disciplined. I'm very  disciplined with my body and my workouts.   But I think there's also the psychological  emotional part, which we do talk about in   the last two chapters of the book, I think  they're the most important pieces because   you can do everything right with your body, and  your mind and your emotions can mess it all up.   So we all know about placebos, obviously,  and most people don't know, they actually   only discovered in World War II, a doctor  who was treating people ran out of morphine,   and as you know, they go into shock  without that, not to mention the pain.   It was actually a nurse that changed the world.  She handed him saline solution and said, "Oh,  

we got some more morphine." Since he believed  it, he told these patients with total certainty,   "You'll be out of pain in the next minute  or two, and you're going to be fine." Well,   none of them went into shock. 90% of them  were out of pain with no drugs. It was just... And so when he came back to Harvard after World  War II, he basically started the standard we now   have for almost all drugs, you're comparing, you  know, to a placebo. But what most people don't   know is you can make yourself sick or well. Now,  first of all, the size of the placebo, the size of  

the invention changes everything, a little pill,  certain reaction, a big pill, more, an injection,   even more. But in the book we gave you also  an example of the veteran's administration   for knee surgeries. They decided to do a third  of the surgeries as sham surgeries, placebo   surgeries, they just put a mark, sewed the person  up, but did nothing to the knee. A year later,   the patients that had no treatment  but thought they had had no pain,   talked about how mobile they were compared to the  ones that were. They don't even fund it anymore.   And it's more than that. I'm sure you know  Harvard's done studies where they take someone  

and give them a real drug, not a placebo,  a barbiturate, it's going to knock you on   the ground and slow you down. And they go,  "Big, giant red pill, this is amphetamine,   you're going to be prepared what's going to do for  you." To a man or a woman, their bodies speed up. So, understanding the power of your mind to  shift things and also your emotions to have   the quality of your life to me is most important.  So, my energy comes from discipline and training.  

It's very intense. I do everything biohacking,  you can imagine. But it's also fulfillment,   and I think success without fulfillment is the  biggest failure in life for anyone. And so,   for me, it's a virtuous circle, I believe  I'm made for this, I'm here to serve,   it doesn't matter the hours, I'll go until we'll  make this thing happen. And I pour so much into   the people, and that energy comes back, and so it  becomes like a turbocharger, and so it gives me an   enormous level of energy. And I'm doing things  at 62 that I wasn't able to do when I was 29,   to give you a [inaudible 00:19:09]. So a lot of  that is some of these tools that we talk about,   but you can't leave out the psychology  and the emotion of your life as well.

[Dr. Patrick]:   Peter, similar question, tell me a little bit  about the lived Peter Diamandis's longevity   routine. Do you have a protocol you follow? Do  you have a comprehensive approach? I know you're   a co-founder of Human Longevity. I'm curious  to know about your... [Crosstalk 00:19:37].

[Dr. Diamandis]: I do, and I value it  more and more every year because I think   the better care I take of myself, the more  likely I am to intercept all of the new biotech   solutions that are coming our way. We can talk  a little about idea of longevity escape velocity   later, which is an idea that we're going to be  scientifically extending our life significantly,   we have to get there. One of my missions, Rhonda,  is making 100 years old [inaudible 00:20:05] 60,   right, have you had 30 or 40 healthy years on our  lives. So, for me, it's the fundamentals, sleep.   I'm religious about getting eight hours of sleep.  We talked about that a little bit. On a diet side,   I have, to the maximum degree possible,  I'm not perfect, but gotten rid of sugar,   right? It's like sugar equals poison, it's a  neuroinflammatory, it causes cardiac disease,   it feeds cancer, there are so many reasons. And  so minimizing sugar and focusing on whole plant,  

more of a Mediterranean diet for  me given my genetics exercise. Now, you know, Tony's probably a lot more  on exercise, but I lift twice a week and I   try and get 10,000 steps a day. And I do some,  you know, lighter exercise, but it's every day,   it's keeping the body in motion. One of  the things I do, Rhonda, that I think it's   so critically important is every year, I go  for a digital upload. What does that mean?   Most of us are optimists about our body.  We think we're fine, don't feel anything,  

you're fine, keep going, you know, you don't  want to go to the doctor, you don't want to know.   But what we have built...and, you know, full  disclosure, Tony and I are co-founders of this   company, we talk about it in the book, because  I think it's so important people to know about   a company called Fountain Life and similar  company called Human Longevity and Health   Nucleus. Once a year I go and get digitally  uploaded. I happen to have done it yesterday. So, I went to the facility in Naples,  Florida, I did a full body MRI,   brain MRI, brain vasculature MRI. And those  MRIs now have very low false positives,  

but I'm looking for any aneurysms, I'm looking  for cancers. And it turns out, historically,   for people in my age group, 2% have a cancer they  don't know about, 2.5% have an aneurysm they don't   know about, and 14.4% have something that's found  that you need to take action on. And so my goal is   to find it at the very beginning at stage zero,  right? I'm going to find something eventually,   and I'm going to say thank you, and I'm going  to take action immediately to try and get it.

Besides the full body MRI, which is looking for  cancers, we do a Grail, you know, liquid biopsy,   which can find 50 different cancers in your  bloodstream. It turns out as cancer cells are   growing and dividing very rapidly, some of the  cells rupture, and you get free floating DNA   in the bloodstream. Well, Grail, which is now  part of Illumina started by Jeff Huber, we can   tell his story, they were able to determine and  find from a blood draw any number of 50 different   cancer DNA sequences, and tell you you've got  cancer someplace in your body then the MRI   can help you localize and find it. Then we do  another thing called a Cleerly coronary CT, right? So, the company's called Cleerly. It's a coronary  CT, is part of this Fountain Life procedure. And   it's an extraordinary AI-driven CT  that is looking for soft plaque. So,   you hear about a calcium score, and people go,  "Oh, my God, I've got 1000 calcium score." Well,  

that's okay because a high calcium score means  that the plaque in your coronary arteries   have been calcified and they're unlikely to  rupture. What really is a concern is soft   plaque, and you've seen people with a zero  calcium score having a heart attack where   the plaque in the side of the coronary arteries  can rupture and then go and block the coronary   artery, starve it from oxygen, your heart  from oxygen, give you a heart attack. But what this AI algorithm does is it's able  to find the soft plaque and then you're able to   monitor it and able to stabilize it. And there's  a whole set of meds that I take. Besides that,  

there's a DEXA scan, there's your genome, your gut  biology, all of your blood tests, 150 gigabytes of   data. And so I do that every year, and I feel  antsy until I get it done. And now, you know,   there's an amazing sense of relief. So, I do that.  There's a whole bunch of supplements, we could   talk about those as well. But, you know, it's  still the basics, right? It's still the basics. [Tony]: Rhonda, you know, I'd love to amplify  that for a second for you. So, you know,  

the National Cancer Society did a study on  100,000 people, and they found that if you   get something at stage three or stage four, you  have an 80% chance of dying, I like it like a 20%   chance of living on what to do. But their point  is well made, it's really hard to turn around.   If you get a stage one or two, you have an 80% to  99.9% chance of survival. And the problem is we   have certain tests, mammograms colonoscopies,  but the ones that usually get us are the ones   that we're not able to find. So, this Grail  test is life-changing in this area. And again,  

the gentleman who created it, lost his wife to  cancer because they found it too late. And most of   the heroes in the book have something in common,  they lost a husband, a wife, a son, or a daughter,   and it pushed them to find answers that were  beyond the standards of care for 20 or 30 years. And on the CCTA test, the Cleerly test,  you know, one of our partners, you know,   he built 12 hospitals, owns 12 hospitals, he's  so tired of sick care. That's why he partnered  

with us to open these Fountain Life Centers.  And he calls me, he's a very understated guy,   because we have this new breakthrough, and he  said, "We've got first access," and he said,   "Tony..." He understates everything, he's talking  real gentle, and he goes, "I really think it's   one of the greatest breakthroughs in cardiology  in 10 years." So him saying that, you listen.   So, he explained to me how it opens up  the arteries and how you get this score   and they can predict the heart attack five  years in advance and show you what to do. So I was with my 80 year old stepfather  happened to be visiting, a great man,   built his own company, lumber company, was always  pretty strong and built, but, you know, got older   and people around him saying, "You're 80, you got  to get your will, you got to get things together."  

I could see these last two or three years just  the energy dropping, again, psychology as much   as physiology. And so I said, "Hey, dad," I  said, "I'm going to go do this test." I explained   it. And I said, "Look, we're both at a stage of  life where we probably have some soft plaques,   but they'll show us where they are and what to do  to clear it up." I said, "Why don't you come?" He   said, "All right." And my father does the test,  and he's clear, I mean, it's like he has no soft  

plaques at all, zero, and his entire mindset  changed, "I was better than I was five years   ago. I'm doing really great," but he literally  had nothing. And then while we're there... You know, there's some brand new techniques that  are amazing, we've worked some of the world-class   athletes, I've had it done. You know, when you  injure yourself, connective tissue can harden up,   and you don't get the fluid, you don't get the  oxygenization or if it traps a nerve. I had an   ankle that for 15, 16 years has bothered me, you  couldn't touch it without their nerves firing off.   And they go in and they use ultrasound,  and they show exactly what's going on.  

They open it with this fluid, you know,  often they'll use something, you know,   that will help heal that process to me in  which process they use. But I had it done,   and it was two years ago, my ankle's perfect. So  I said to my dad, what makes him feel old is pain   and not able to walk so well, your hip problem.  So he now knows his heart's perfect. So I said,   "Dad, why don't you let these guys look at you  here? And you know what I did to my ankle." So they looked and found two locations where it  was all being locked down, open it up with some of   this fluid, about a half hour later, he's walking  perfectly, I mean, smoothly zero pain. So we get  

on the plane, he crosses his arms, and he goes,  "You know, these people talk about living 110,   120. I don't know if I buy that because, you  know, Tony, my heart's perfect, you know,   I'm walking perfect. I could live another 20  years. I could live to 100, and you've only known   my daughter for 22 years," he goes, "like another  lifetime." It completely changes psychology. So it's not just about, "Oh,  my God, I need to do this."   It's like ignorance is poverty, ignorance  is pain, ignorance can be death. And today,  

there are some tools there that can change  it all, and they're very fundamental. One more, hormones, every woman, you know,  especially women in their 30s or 40s, knows   about hormones because of menopause, but hormone  replacement therapy is usually at the point where   there's a problem. And now, as you know, there's  precision, there's hormone optimization therapy.   And even for men. Like we had a gentleman come  in, and he was 36 pounds overweight, listless,   frustrated with his life, working  out hard, nothing working, said,   "We looked at your hormones." He goes, "Oh, yeah,  they're fine...they're just fine." We look up and   do the hormone test, and his testosterone thing  was like 225. Well, most doctors won't intervene  

until it's like 175. Most men don't feel alive  if they're not in the 700, 800, 900 range.   So, small change in his life, in three months,  he loses 36 pounds, he feels 10 years younger,   your life changes. So, it isn't just about  avoid disease, it's about optimization,   it's about what do you do right now that can  give you the quality of life that maybe you had   earlier or you maybe never had  because things weren't in balance. [Dr. Patrick]: Let's shift gears and talk  about more big picture. Let's talk about   the aging process in general. And, Peter, I  know you have some interesting opinions on this. [Dr. Diamandis]: I do. Yeah. So, I mean,  one of the questions to ask yourself is  

why do we age. I mean, you've got the same genome  when you're born as you do when you're 20 and 40   and 60 and 80, and you live to 100, same genome  at 100, right, 3.2 billion letters from your mom,   3.2 billion letters from your dad. Why don't  you look like you look when you're in your 20s?   Well, it turns out it isn't your genes, it's  which genes are on and which genes are off,   it's the regulation of your genes which we  call the epigenome from the Greek word for   above, you know, the regulation above the genome.  And it's a challenge to understand this. You know,   the breakthrough is in the last decade, and Dr.  David Sinclair, who wrote an incredible book   "Lifespan" that talks about this, does a great job  there. But your epigenome, the analogy I used in  

the book is that your genes, which are not your  destiny, they are part of your destiny but not   your destiny, your genes are sort of the keys of  a piano, and your epigenome is the piano player. Now, it turns out that the control of your  epigenome in part is handled by seven sirtuin   genes and seven sirtuin enzymes, and those  sirtuins have two primary functions in life.   Number one, they control your epigenome,  they control which of your genes are on and   which of your genes are off. The other thing  it does, which is massively significant for   your life, is they facilitate DNA repair, and  so as we're getting older and we're exposed   to radiation, you know, flying in airplanes, or  smoke, or, you know, chemicals in the environment,   and we start getting...accumulating more and  more DNA damage, your sirtuins are spending  

more and more time repairing your DNA instead of  controlling which genes are on and which genes   are off. And there's just this constant struggle  back and forth. And as you get older because the   function of DNA repair is so critical, they're  basically distracted from their epigenome. And then, you know, Tony talked about this concept  of NAD as sort of a fuel in the cell that powers   these sirtuins. And we can talk more in detail  here. But the NAD in your mitochondria inside your   cells, you know, is pretty good in your teens,  20s, and 30s, but then in your 40s into your 50s,   it falls off rapidly. So just when you need more  active sirtuins as the DNA damage is increasing,   the fuel supply for the sirtuins starts  plummeting, and then all of a sudden, you're   not able to, you know, control your epigenome,  and we get aging, we get aging significantly.   And so, that's just fundamental right now, and  the question is, how do you change it? How do   you fix it? How do you upregulate the NAD in your  cells? And how do you, you know, really focus your   sirtuins and give them the ability to focus on  both the DNA repair and the epigenome control? [Tony]: And one of the pieces that NAD  does that I'm sure you probably know   is it also affects the mitochondria directly,  the ability to build energy in the cell.  

The sirtuins need the NAD for fuel, but  NAD needs NMN as I know you know as the   precursor to make all that possible. Well,  you can go get NMN, but with Dr. Sinclair,   we studied six companies, we took their products,  see how much NMN are you really getting,   and there was none in any of the products. Some  were $30 a month, some were $120 a month. Last,   the lab guy said, "I mean, are these people  just cheats? A lot of it comes from China."  

And he said, "Well, they could be, some do,"  but he said, "It breaks down in 30 to 45 days,   so by the time somebody gets this product,  it's usually inert." I said, "That's insane." So David has come up with his own products,   but he's also done something even more amazing.  He's partnered up with a group called EdenRoc,   and this group... Well, let me first  tell you, NMN, if you take an old mouse,  

meaning like a 70 year old equivalent as a human  is about a 24 month mouse, as I'm sure you know,   and you put them on, you know, a running platform,  they can go maximum of a quarter of a kilometer.   But a young, powerful mouse can do four times  as much, a full kilometer. Well, 14 days on NMN,   and now the NAD gets in because the absorption  is about 30%. And that same animal that's   equivalent of seven year old animal  will run two to three kilometers,   200 to 300% more than the younger, strongest  animals. But then the question you got to ask  

yourself is, "Well, mice studies are nice,  but do they really translate to humans?" So, EdenRoc put together 100 of some of the people  we all know, some of the greatest researchers out   there, and unlike some of these other companies,  they have really focused on developing a product.   And the product was, "Okay, how do we create an  NMN that can sustain and be more absorbable?"   And they came up with a synthetic  crystallized form. It's called MIB-626,   and unbeknownst to the rest of the world,  but it's now out. As of about two weeks ago,   the "Daily Mail" talked about it. It got out.  They've been working with our special forces   for two years. They proved its safety, then they  proved its efficacy. And the FDA is now doing a  

parallel study. But this commander got so excited  that he let the beans spill. I can't tell you the   specifics because I'm an investor in the company,  but I can tell you what he said so you know. He acknowledged the fact that what they  saw happening with mice happen with the   strongest men and women that we know. They  don't have that much more to get better,   they're so strong. But he said their endurance  exploded, their muscle development from the same   stimulus increased significantly, but the  most powerful thing was cognition because   when you're out there under stress and you're  exhausted, can you keep your brain together?   The studies I have been doing now because I'm  sure you know, with COVID, it goes into your   mitochondria and basically steals some of the  energy, that's part of the problem with fatigue.

So there's a phase three trial going on right now  to prevent COVID and for long-term COVID. There's   one on kidneys because the impact it has with  COVID, and then they have these endurance ones.   So their projection right now is they believe  they'll get approval in the next 24 months,   perhaps as early as 18, but more likely  24 months. It will not be a nutraceutical,   it will be a sustained crystallized form  that you can get from your doctor. So imagine   there's a natural substance in your  body that is dropped by more than 50%,   and now you can supplement it with something  that has 300% absorption more than you would   have had before that now turns on and off the  right genes, reduces inflammation in the body,   we all know is the basis of it, and helps your  mitochondria have more energy while simultaneously   helping those sirtuins to clean up your DNA damage  all at one time. So these are some of the things  

that...there's things you can do right now like  NMN, but those are the things that are coming   in the next 12 to 36 months that are truly life  changing. That's one of them that excites us. [Dr. Patrick]: Wow. Well, I look forward  to seeing that data. It's interesting.   I've had sort of mixed feelings with...not  

mixed feeling, I mean, my excitement. I've been  holding my excitement back a little bit. I had,   you know, David on the podcast a couple of  years back, and we talked about a lot of this   research. And there was some evidence that taking  either NMN or [nicotinamide] ribonucleotide... [Dr. Diamandis]: NR. [Dr. Patrick]: ... NR, you know, can increase  NAD levels in humans in the blood. But there  

was a study, I think it was the Rabinowitz  Lab published that this was in animals,   you know, that even really, really high doses of  both of these precursors, NAD precursors...both NR   and NMN were unable to raise NAD levels in other  tissues outside of the liver. So, muscle brain,   for example, there was no change. And there's  a lot of mechanisms involved in that. But like,   you know, I'm wondering if some of the effects  you were talking about also may be indirect   from raising it in the blood perhaps, maybe  that's signaling each other [crosstalk 00:37:12].

[Tony]: It very possible, but they've just got the  blood back two weeks ago, including what's in the   muscles, and again, I can't reveal because I'm not  at liberty to do that. But what I can tell you is   they're very excited about what they've seen,  it's greater response than they had hoped for. [Dr. Patrick]: Awesome, super cool. In  addition to the sirtuins, which are one   very important and interesting piece to the aging   puzzle, I know that you are aware of some of  the technology and research that have come   out of Juan Carlos Belmonte's lab at the Salk  Institute where he has shown that you can take   phenotype for a mouse, which is an accelerated  aging phenotype, and add these four...

[Tony]: Yamanaka factors. [Dr. Patrick]: ...the Yamanaka factors,  which for people, you know, listening,   these are four different transcription factors  that were discovered by Dr. Shinya Yamanaka.   Was it 2006? I [crosstalk 00:38:12] [Dr. Diamandis]: Got the Nobel Prize. [Tony]: Yeah, got the Nobel Prize. [Dr. Patrick]:   For figuring out that these transcription  factors if you add them to an adult cell,   a cell that's perhaps a skin cell or a kidney  cell, you can completely reprogram that cell   into a pluripotent stem cell that can become any  type of cell like we were talking about, you know,   the placenta being a source of. And so it sort of  reprograms that epigenome that, Peter, you were  

talking about into a clean slate and allows it to  then become a new cell type. But what, you know,   Juan Carlos Belmonte's lab, and there's some  others that have done this in vitro, but he was   really the first to show this in an animal, it's  called interrupted cellular reprogramming, where   you don't want to make an adult cell lose its  identity, you want it to just basically wipe the   program free but still be the same cell. So you  want it to become, you know, younger, so to speak. So, he showed this proof of principle study that  adding these Yamanaka factors but pulsing them   throughout the life of these animals  that have an accelerated aging phenotype,   he could essentially reverse aging. And it was, to  me... I mean, I got chills when I read this study.  

It's like, this is it. This is what  I've been looking for, you know. [Tony]: You know about Dr. Sinclair's  work, with restoring the mice's   vision, using the three of  the four Yamanaka factors?   [Crosstalk 00:39:43]. Tell her about that,  just to make sure the audience knows.

[Dr. Diamandis]: I mean, it was the cover of  "Science" in December of 2020. It was, like,   you know, landmark work, where instead of using  all four Yamanaka factors, David took in a mouse   that had aged out, it'd become blind with glaucoma  and lost its sight. And he gave it three of the   four Yamanaka factors without retaining not one  of them that causes cancer. And lo and behold, the   visual system of the mice became young again,  to the point where they regained their vision.   And it's since been repeated in the cardiac  system of mice. And, you know, George Church,   another Harvard genomicist who you know, is now  working on doing this in dogs. And when you ask  

David and George when they think these Yamanaka  transcription factors, is effectively a gene   therapy, to create this youthfulness. When  we might see that in humans, you know,   in early trials, it blows me away when they say  it's gonna be this decade. Right? That is amazing. [Dr. Patrick]: Totally amazing. I  have a sort of tangent question. And   just out of my own curiosity, Peter, want to know  your thoughts on this, because I know  

that there's a company forming that's recruiting  some of the top aging researchers and recruiting   them out of academia. In some cases, they're, you  know, luring them with... And academia doesn't   pay scientists glamorous salaries, unless,  you know, they discover...start a company,   a biotech company and get lucky, whatever. And  so, you know, this company's getting the biggest   names in aging and putting them all together.  And I'm super excited because one of the,   you know, big areas they're going to explore  is this interrupted cellular reprogramming.   I'm just interested what your thoughts are,  like, the pros and cons of [crosstalk 00:42:15].

[Dr. Diamandis]: Well, I got excited about it,  too. And I know, you know, Yuri Milner and Jeff   Bezos, who funded this. And a friend of mine,  Morgan Levine, who was at Yale, got sucked up into   this, and she's now a founding principal moving  to where you are, down in San Diego. So, it's very  

cool. I mean, this is in the context of probably  $5 billion to $10 billion a year, going into age   reversal, longevity, health span expanding  research. Right? So, that's Altos Labs. We   just saw Brian Armstrong, Co-Founder of Coinbase,  start a new company called NewLimit, to go after   this, you know, using gene therapy  to extend a healthy human lifespan.   We've seen the Kingdom of Saudi Arabia and the  Crown Prince in Dubai co-fund something called   Hevolution to billions of dollars. Where  it's a nonprofit, but they're investing in   extending the healthy human lifespan. I mean,  you know, Tony and I talk about this, is that,  

health is the new wealth. And I don't think  there's a bigger marketplace on the planet, right? It's like, you still can't take it with  you. And if you could spend your money to   extend your lifespan, it's massively valuable.  Now, the question I think you're asking is,   is that going to make people less hungry to do  this, having a fat checkbook? I mean, I remember   we were talking about this before, you know,  Google created Calico, which stands for California   Longevity Company, or something like that. And,  you know, invested billions of dollars. They're  

hired Art Levinson, who is also the chairman of  Apple and was the CEO of Genentech, to run Calico.   And, you know, the question is, are we seeing  revolutionary research and breakthroughs coming   out of these kinds of companies? Or do we  need this to be in the university world?   I'm a libertarian capitalist. I always think  companies are going to go faster, and take more   risk, and do stronger work. So, my bent is to be  more excited than less excited. But then again,   you know, I'm also doing an age reversal XPRIZE  because I want to get as many labs and companies   around the world competing to solve this problem.  Because, you know, every day I'm getting older. [Tony]: Well, you know, EdenRoc, one  of the reasons I invested in them,   they have a different approach. They have an  incentivized approach for all of them. So it's all   based on rewards and performance. It's not a fat  check. And personally, I prefer that strategy. I  

think the competitive strategy, having to produce  a result to be rewarded is very different than   somebody getting comfortable and taking their  time to do the research without being tied to   an outcome or a measurable result. So, I'm really  impressed, what I've seen come out of there,   but I'm thrilled that everybody's doing it. And  I think Peter's XPRIZE is a great gift because   get all these people competing... You know,  at least historically, as we all know, that  

usually brings the greatest result. But listen,  having this much capital, this many brilliant   minds, all being driven to try  to resolve the riddle of aging.   It looks really damn good for us. You know, you  might want to come back to, Peter, I don't know,  

mentioning, you know, escape velocity and  what that really means in terms of time. [Dr. Diamandis]: Yeah. So, it's interesting,  there's a concept called longevity escape   velocity. Rhonda, I know you know this, but your  viewers and listeners, I think it's important.  

Today, we're seeing this massive investment  in biotech and health tech. And it's   lengthening our lifespan, right? So,  100 years ago, the average lifespan was,   you know, under 40. Today, it's in the upper 70s.  Hopefully, soon, it will be in the 90s and 100s.   But on the average, every year that you live,  science extends your life by about a quarter of   a year. So for every four years, you're adding an  additional year. Well, there's a concept called   longevity escape velocity that Ray Kurzweil talks  about. Ray wrote our opening intro for the book.   And the concept is that, there's going to  be a point, as science continues to advance,   that for every year you're alive, scientists  extend your life for greater than a year. And all of a sudden, it's a departure where you're  living long enough to live forever. And so the  

question I asked Ray was, when do you expect  we're going to see longevity escape velocity?   And I was sort of shocked by his answer. He said,  "Probably in about a dozen years." But then what   I was even more excited about was, you know, I  said, Ray's an optimist about technology. He's got   30 years of predictions that have an 86% accuracy  rate, if you go and Google Ray Kurzweil's   predictions. So, he's pretty good at predicting  things. And I went on to George Church at Harvard   Medical School, I was interviewing him for this  book, and I just threw it. I said, "George,   you know, you're talking about longevity escape  velocity, when do you think we're going to hit   it?" And he said, "Probably within 15 years." And  I'm, know, it just blew my mind. That   idea that if we're able to stay healthy enough to  really be in reasonable shape 15 years from now,   that we're going to intercept technologies  that can add additional decades onto our life.

And then by the way, during those  additional decades, science isn't stopping,   it's accelerating. So you're going to  intercept even more technologies that add   decades to your life. So this is a magical  time to be alive. And as I tell everybody,   and my family and friends, and in this book, you  know, you just don't want to die from something   stupid in the interim. Wear your helmet  when you're skiing, wear your seatbelt,  

do your uploads, find cancer, if you're gonna  have it, you know, at the very beginning. [Dr. Patrick]: We've talked a lot about, you know,  cellular rejuvenation, about the Yamanaka factors,   epigenetic clock reversals, sirtuins, all these  really exciting aspects and technologies in the   field of aging. And it's really striking in  some ways that the mechanism for some of these   facets of biological age, they already seem  to be here, in us, and yet evolution seems   to have mostly withheld it from us. Have  you given any thought, Peter, as to... [Dr. Diamandis]: Yeah. We're, like, what up? Why?  Why? You know, first of all, you have to realize  

that there are species on this planet, the bowhead  whale lives 200 years old, the Greenland shark can   live 500-plus years old. I remember when I  was in medical school, I was watching this   TV show on long-lived sea life. And I was saying,  "Well, if they can live, like, hundreds of years,   why can't we?" And I remember in that moment in  time, I said, "It's either a hardware problem or   a software problem, and we're going to be able  to fix it." Well, that time I believe, is now,   it's the next few decades. And it turns out that  we were never engineered to live past age 30.   You know, we would go into puberty at age 12 or  13. Before birth control, we'd be pregnant by   age 13 or 14. And then by the time you were 27,  28, 29 years old, your baby was having a baby.

And if you wanted to perpetuate the human species,  the worst thing you could do was to eat the food   that was going to go to your grandchildren,  because they died. And, you know, ultimately,   we were not intended to live past age 30.  We would die, give the food supplied to our   next generation. And so, none of the factors  that we're seeing, in terms of dysregulation,   loss of optimization of our hormones, growth  factors, all of these things. You know,   we dysregulate after the age of 30, we see this  plummeting of the stem cell know,   stem cell exhaustion in the body because it was  never selected against. And what we're trying to  

do now instead of, you know, Darwinism, this is  evolution by human intelligence. We're trying to,   like, change the clocks, and change the factors,  and add them back in, and get us back to optimal   state of what we were like in our 20s and 30s.  And we're doing it by supplementation. Soon,   we'll be doing it using gene therapies and CRISPR.  But the idea that, you know, there's some magic   limitation that we can't overcome, I don't believe  it. I do believe we're going to be able to add   many decades, perhaps centuries on to our life.

[Tony]: And that brings up a different question,  which is, most people do not have a full life   living to age 65 or 70, in terms of fulfillment.  And so the real question is, what do you do when   life is no longer scarce? Because scarcity  does create some sense of value, right? I want   to take advantage of what's here. And, you know,  there's an old Twilight Zone piece that actually   Ray Kurzweil told me about decades ago. And it  goes like this. It's a man who dies and he goes  

to have intercourse. He's a gambler, so heaven is  Vegas. And where does he find himself? The top of   the number one hotel. He's in the presidential  suite. He opens up the drawers and the cupboards   and everything, and he has brand new suits and  jewelry, he puts it on. There's credit cards   and cash. He goes down and he starts to gamble.  And sure enough, he gambles playing 21, 21, 21,   21, blackjack, blackjack. He wins continuously.  Suddenly, there's a group of women around him.

Now he goes and rolls the dice, he's playing  craps, he wins, he wins, he wins, he wins.   He's out of his mind. He goes home that night.  He's not alone. He's quite happy with the people   that are joining him, and the situation that he's  going in. He wakes up the next morning, and he   starts the whole thing all over again. After three  weeks of doing this, he starts to get pissed.   He gets angry. And at one point, you  win, you win, you win, And he says,  

"I always win." And he says, "I want to  talk to the head angel. I want to talk to   the head angel." And they bring this man who  looks like Guy Lombardi in a tuxedo. And he   walks up and he says, "Sir, is there a problem?"  He said, "Yes." He said, "I'm constantly winning.  

I win every time." He said, "Listen, I wasn't  that good a person. I don't like this." He said,   "I'm not supposed to be in heaven." And the  angel said, "Who said you're in heaven?" And the idea is that, if we just got everything we  wanted, if there was no limitation on everything,   would we find the meaning? And I think  that's gonna be the next lesson for humanity,   is finding how we use this additional  time and these additional resources   for something greater than ourselves. Because  what fulfills people is not just hanging out   and living. When you look at it, it's one  primary emotion, it's progress. It's feeling   like you're growing. And because you're growing,  you have something to give. If you don't grow,   it doesn't matter how much money you have, it  doesn't matter how many p

2022-03-10 14:48

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